Objective: To study the clinical significance of detecting of beta 2-microglobulin (beta 2-MG). Fibronection (Fn) and interleukin 2 (IL-2) in patients with nasopharyngeal carcinoma.
Method: The levels of serum beta 2-MG and IL-2 in 32 patients with nasopharyngeal carcinoma were determined by radioimmunoassay, radial immunodiffusion and ELISA before and after radiotherapy.
Result: The levels of serum beta 2-MG in patients with nasopharyngeal carcinoma were significantly higher than that in controls (P < 0.05); but serum Fn and IL-2 in patients were significantly lower than that in controls (P < 0.05). The level of serum beta 2-MG decreased in patients after radiotherapy, but the serum Fn and IL-2 increased in patients after radiotherapy.
Conclusion: Detection of serum beta 2-MG, Fn and IL-2 was useful in clinical diagnosis and prognosis observation of nasopharyngeal carcinoma.