Abnormal production of interleukin (IL)-11 and IL-8 in polycythaemia vera

Cytokine. 2002 Nov 24;20(4):178-83. doi: 10.1006/cyto.2002.1994.

Abstract

We studied the production of interleukin (IL)-11 and IL-8, two cytokines known to affect erythropoiesis, in polycythemia vera (PV). In vivo, IL-11 was detected more frequently in serum and bone marrow (BM) plasma of PV patients than in controls (healthy donors and patients with idiopathic erythrocytosis (IE)). In addition, serum IL-11 levels of PV patients were higher than those of controls. IL-8 was elevated in serum of both PV and IE patients (respective median levels: 38.6 and 242pg/ml, vs 4.4pg/ml for healthy donors). BM plasma IL-8 levels of PV patients (508pg/ml) were significantly higher than those of IE patients (120pg/ml). In vitro, bone marrow (BM) stromal cells (BMSC) of PV patients produced significantly more IL-11 (x6.4) and IL-8 (x8.3) than BMSC of healthy donors or IE patients. In conclusion, both IL-11 and IL-8 are overproduced in PV, apparently by BMSC; IL-8 is also overproduced in IE, by cells other than BMSC.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Marrow Cells / drug effects
  • Bone Marrow Cells / metabolism
  • Cells, Cultured / drug effects
  • Cells, Cultured / metabolism
  • Humans
  • Interleukin-1 / pharmacology
  • Interleukin-11 / biosynthesis*
  • Interleukin-11 / blood
  • Interleukin-8 / biosynthesis*
  • Interleukin-8 / blood
  • Polycythemia / blood
  • Polycythemia Vera / blood*
  • Stromal Cells / drug effects
  • Stromal Cells / metabolism

Substances

  • Interleukin-1
  • Interleukin-11
  • Interleukin-8