Synthesis and potential antimetastatic activity of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-glucopyranosides

Qing Li; Bin Su; Hui Li; Xiang-Bao Meng; Meng-Shen Cai; Zhong-Jun Li; Rou-Li Zhou; Ta-Lin Suo

doi:10.1016/s0008-6215(02)00438-x

Synthesis and potential antimetastatic activity of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-glucopyranosides

Carbohydr Res. 2003 Jan 31;338(3):207-17. doi: 10.1016/s0008-6215(02)00438-x.

Authors

Qing Li¹, Bin Su, Hui Li, Xiang-Bao Meng, Meng-Shen Cai, Zhong-Jun Li, Rou-Li Zhou, Ta-Lin Suo

Affiliation

¹ Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.

PMID: 12543553
DOI: 10.1016/s0008-6215(02)00438-x

Abstract

Anomers of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-gluco-pyranosides were synthesized under different glycosylation conditions, and evaluated for in vitro antimetastatic activity. Three compounds showed promising inhibitory effects on cancer cell attachment, spreading, migration, and invasion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Sugars / chemical synthesis*
Amino Sugars / pharmacology*
Cell Adhesion / drug effects
Cell Movement / drug effects
Glycosylation
Humans
Laminin
Neoplasm Invasiveness / prevention & control
Neoplasm Metastasis / drug therapy*
Neoplasm Metastasis / pathology
Neoplasm Metastasis / prevention & control
Tumor Cells, Cultured

Substances

Amino Sugars
Laminin
N-acetyllactosamine