Lymphangiogenesis new mechanisms

Ann N Y Acad Sci. 2002 Dec;979:111-9. doi: 10.1111/j.1749-6632.2002.tb04872.x.

Abstract

A mouse model has been developed to study lymphangiogenesis dissociated from angiogenesis. bFGF implanted in a mouse cornea at a concentration below the threshold to induce angiogenesis potently induces lymphangiogenesis. This model has permitted a study of cellular and molecular mechanisms of lymphangiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology
  • Animals
  • Corneal Neovascularization / physiopathology
  • Corneal Neovascularization / prevention & control
  • Corneal Neovascularization / therapy
  • Disease Models, Animal
  • Fibroblast Growth Factor 2 / pharmacology
  • Humans
  • Lymphatic Diseases / physiopathology
  • Lymphatic System / blood supply*
  • Mice
  • Neovascularization, Pathologic / physiopathology*

Substances

  • Angiogenesis Inhibitors
  • Fibroblast Growth Factor 2