Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 15 (1), 17-23

Thrombocytopenia in the Newborn

Affiliations
Review

Thrombocytopenia in the Newborn

Irene A G Roberts et al. Curr Opin Pediatr.

Abstract

Thrombocytopenia remains a common problem in sick newborns. A quarter of all neonates admitted to neonatal intensive care units develop thrombocytopenia, and in 20% of episodes the thrombocytopenia is severe (platelets <50 x 10(9)/L). Practical and clinically relevant classifications of neonatal thrombocytopenia have now been developed which, by highlighting the principal conditions precipitating severe thrombocytopenia (eg, sepsis, necrotizing enterocolitis, perinatal asphyxia, and the immune thrombocytopenias), aid the practicing neonatologist. Recent reviews demonstrate that many neonates with severe thrombocytopenia receive repeated platelet transfusions, although evidence of their clinical benefit is lacking, and there exists a significant variation in platelet transfusion practice between centers. These facts support the need for the development of evidence-based protocols for platelet transfusion in the newborn and stimulate continued interest in the potential of hemopoietic growth factors (, thrombopoietin and interleukin-11) to prevent or treat neonatal thrombocytopenia.

Comment in

Similar articles

  • Evaluation and Treatment of Thrombocytopenia in the Neonatal Intensive Care Unit
    NA Murray. Acta Paediatr Suppl 91 (438), 74-81. PMID 12477267. - Review
    While improving this situation remains a pressing need, the growing evidence that impaired megakaryocytopoiesis and platelet production are major contributors to many neo …
  • Neonatal Thrombocytopenia
    IA Roberts et al. Curr Hematol Rep 5 (1), 55-63. PMID 16537047. - Review
    Neonatal thrombocytopenia is a common clinical problem. The majority of episodes are early-onset thrombocytopenias due to impaired fetal megakaryocytopoiesis associated w …
  • Neonatal Platelet Transfusions and Future Areas of Research
    M Sola-Visner et al. Transfus Med Rev 30 (4), 183-8. PMID 27282660. - Review
    Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered …
  • Evaluation and Management of Thrombocytopenic Neonates in the Intensive Care Unit
    A Del Vecchio. Early Hum Dev 90 Suppl 2, S51-5. PMID 25220130. - Review
    Thrombocytopenia is a very frequent problem among sick neonates, affecting up to 35% of all infants admitted to the neonatal intensive care unit (NICU), and serves as an …
  • Neonatal Thrombocytopenia
    S Chakravorty et al. Early Hum Dev 81 (1), 35-41. PMID 15707713. - Review
    Thrombocytopenia occurs in up to a third of preterm neonates admitted to intensive care units. In these babies, thrombocytopenia typically presents in one of two patterns …
See all similar articles

Cited by 9 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback