Femoral central venous catheter-associated deep venous thrombosis in children with diabetic ketoacidosis

Crit Care Med. 2003 Jan;31(1):80-3. doi: 10.1097/00003246-200301000-00012.


Objective: To describe the incidence of clinical deep venous thrombosis associated with femoral central venous catheters (CVC-DVT) in children with diabetic ketoacidosis (DKA).

Design: Retrospective case-matched control series.

Setting: Pediatric intensive care units of two university-affiliated hospitals.

Patients: All eight pediatric DKA patients with femoral central venous catheters between 1998 and 2001, and 16 age-matched control patients with femoral central venous catheters and circulatory shock.

Interventions: None.

Measurements and main results: The records of all children with DKA and the control patients were reviewed. CVC-DVT was defined as persistent ipsilateral leg swelling after removal of a femoral central venous catheter. Control patients with coagulopathies, thrombocytopenia, cancer, and hyperglycemia were excluded. Four of eight patients with DKA developed CVC-DVT compared with none of the 16 control patients (p = .007, Fisher's exact test). All four patients with DKA and CVC-DVT were <3 yrs old. Doppler ultrasound examination was performed on three of the four patients with clinical CVC-DVT, confirming the diagnosis in each case.

Conclusions: This study suggests that young children with DKA have an increased incidence of clinical DVT associated with the placement of femoral central venous catheters.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Catheterization, Central Venous / adverse effects*
  • Child
  • Child, Preschool
  • Diabetic Ketoacidosis / therapy*
  • Female
  • Femoral Vein*
  • Humans
  • Incidence
  • Infant
  • Male
  • Matched-Pair Analysis
  • Retrospective Studies
  • United States / epidemiology
  • Venous Thrombosis / epidemiology*
  • Venous Thrombosis / etiology*