Is HIV sequestered in bone? Possible implications of virological and immunological findings in some HIV-infected patients with bone disease

AIDS. 2003 Jan 24;17(2):255-7. doi: 10.1097/00002030-200301240-00016.


To determine the prevalence of CD4 lymphocyte levels less than 350 cells/mm3 accompanying viral loads (VL) less than 500 copies/ml (discordant CD4 lymphocyte levels/VL) in HIV-infected men with bone pathologies, we conducted a review of the records of 3512 men. We found discordant CD4 lymphocyte levels/VL in 26 (36.1%) out of 72 with bone pathologies, and in 704 (20.5%) out of 3440 without bone pathologies (P < 0.01), and concluded that HIV sequestered in bone was a possible explanation.

MeSH terms

  • Bone Diseases / virology*
  • CD4 Lymphocyte Count
  • HIV Infections / complications*
  • HIV Infections / immunology
  • HIV Infections / virology
  • Humans
  • Male
  • Viral Load