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. Nov-Dec 2002;21(6):216-8.

Effect of Omeprazole on Plasma Zinc Levels After Oral Zinc Administration

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  • PMID: 12546170

Effect of Omeprazole on Plasma Zinc Levels After Oral Zinc Administration

A Omer Ozutemiz et al. Indian J Gastroenterol. .

Abstract

Background: The intestines are the major site of zinc absorption and excretion. Reduced gastric acid secretion and elevated gastric pH is an important factor affecting intestinal mineral absorption.

Methods: Gastric pH and volume, and basal and maximal acid outputs were measured in 14 healthy volunteers. Plasma zinc levels were then measured at baseline and 1, 2, 3 and 4 hours after oral administration of 300 mg zinc sulfate. The experiment was repeated after omeprazole administration (60 mg/day orally) for 7 days.

Results: Omeprazole administration significantly increased fasting gastric pH (5.5 versus 2.4; p < 0.001). Mean basal gastric acid output (1.6 vs 8.0 mEq/h; p < 0.001) and maximal acid output (20.6 vs 106.6 mEq/h; p < 0.001) decreased after omeprazole administration. Zinc absorption decreased after omeprazole administration (141 [34] mg/dL/h) compared with pre-omeprazole values (245 [35]; p < 0.01).

Conclusion: Suppression of gastric acid secretion by omeprazole reduces intestinal absorption of zinc.

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