Efficacy and safety of oral sodium phosphate versus polyethylene glycol solution for bowel preparation for colonoscopy

Indian J Gastroenterol. 2002 Nov-Dec;21(6):219-21.


Objective: To assess the acceptability, safety and effectiveness of an oral sodium phosphate solution (Exelyte) for colon preparation prior to colonoscopy, compared with a polyethylene glycol solution (Peglec).

Method: A colonoscopist-blinded, prospective, randomized, observational clinical study.

Patients: One hundred patients undergoing colonoscopy for various indications were randomized (n = 50 each) to receive either 90 mL of oral sodium phosphate mixed with 300 mL clear liquid and then consume about 4-5 glasses of water, or 2 liters of polyethylene glycol solution.

Result: Sodium phosphate showed a safety profile similar to that of polyethylene glycol. However, patients tolerated it better. The colonoscopist reported similar cleansing of bowel in both groups.

Conclusion: Oral sodium phosphate is well tolerated, is safe and provides bowel cleansing similar to that with a polyethylene glycol solution.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Colonic Diseases / diagnosis*
  • Colonoscopy*
  • Enema / methods*
  • Humans
  • Male
  • Middle Aged
  • Phosphates / administration & dosage*
  • Polyethylene Glycols / administration & dosage*
  • Prospective Studies


  • Phosphates
  • Polyethylene Glycols
  • sodium phosphate