Hepcidin, a new iron regulatory peptide

Blood Cells Mol Dis. Nov-Dec 2002;29(3):327-35. doi: 10.1006/bcmd.2002.0573.

Abstract

Maintaining normal iron homeostasis is essential for the organism, as both iron deficiency and iron excess are associated with cellular dysfunction. Recently, several lines of evidence have suggested that hepcidin, a peptide mainly produced by the liver, plays a major role in the control of body iron homeostasis. The subject of this paper is to summarize the advances toward the understanding of function and regulation of hepcidin in iron metabolism and to provide new data on the regulation of hepcidin gene expression by erythropoietin, the major regulator of mammalian erythropoiesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antimicrobial Cationic Peptides / genetics
  • Antimicrobial Cationic Peptides / metabolism*
  • Erythropoietin / metabolism
  • Gene Expression Regulation / physiology
  • Hepcidins
  • Iron / metabolism*
  • Mice
  • Molecular Sequence Data

Substances

  • Antimicrobial Cationic Peptides
  • Hamp protein, mouse
  • Hepcidins
  • Erythropoietin
  • Iron