Pharmacokinetics of 125I-iothalamate and 131I-o-iodohippurate in man

J Clin Pharmacol. Feb-Mar 1976;16(2-3):142-8. doi: 10.1002/j.1552-4604.1976.tb02395.x.

Abstract

The pharmacokinetics of 125I-iothalamate (IOT125I) and 131I-o-iodohippurate (OIH131I) have been studied in patients with varying degrees of renal insufficiency. Both compounds have been shown to obey two-compartment model kinetics after intravenous administration. The clearances are closely related to renal function, but poor correlations were obtained between renal function and compartmental distribution characteristics. This study provides further evidence that IOT125I and OIH131I may be used as indicators of renal function in patients after a single intravenous injection.

MeSH terms

  • Blood Urea Nitrogen
  • Creatinine / metabolism
  • Half-Life
  • Humans
  • Iodohippuric Acid / metabolism*
  • Iothalamic Acid / metabolism*
  • Kidney Failure, Chronic / metabolism
  • Kinetics
  • Male

Substances

  • Iodohippuric Acid
  • Iothalamic Acid
  • Creatinine