Searching for nuclear-mitochondrial genes

Trends Genet. 2003 Feb;19(2):60-2. doi: 10.1016/s0168-9525(02)00030-6.


Recently, a novel strategy has been developed to identify yeast genes that are important for mitochondrial respiratory chain function. This approach found a large number of genes that were not previously thought to be involved, providing new candidate disease genes for mitochondrial disorders. These genes could cast light on the intricate relationship between genotype and phenotype in a wide range of inherited human diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics*
  • DNA, Mitochondrial / genetics
  • Electron Transport / genetics
  • Genes, Dominant
  • Genes, Recessive
  • Genetic Diseases, Inborn / genetics*
  • Humans
  • Mitochondria / genetics*
  • Mitochondrial Diseases / genetics
  • Mitochondrial Proteins / genetics
  • Point Mutation


  • DNA, Mitochondrial
  • Mitochondrial Proteins