Immunostimulating reconstituted influenza virosomes

Vaccine. 2003 Feb 14;21(9-10):921-4. doi: 10.1016/s0264-410x(02)00541-8.

Abstract

Immunostimulating reconstituted influenza virosomes (IRIVs) are a liposomal carrier system. Influenza hemagglutinin and neuraminidase are intercalated into the lipid bilayer and give the IRIVs their fusogenic activity. The system is already registered for human use and allows a specific targetting of antigens to a cellular or a humoral immune response. IRIVs are able to deliver proteins, RNA/DNA, peptides and mimetics to immunocompetent cells.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Animals
  • B-Lymphocytes / immunology
  • Humans
  • Influenza Vaccines / administration & dosage*
  • Liposomes
  • Microscopy, Electron
  • T-Lymphocytes / immunology
  • Virosomes / administration & dosage*

Substances

  • Adjuvants, Immunologic
  • Influenza Vaccines
  • Liposomes
  • Virosomes