Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report

Ther Drug Monit. 2003 Feb;25(1):117-9. doi: 10.1097/00007691-200302000-00019.

Abstract

This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.

Publication types

  • Case Reports

MeSH terms

  • Area Under Curve
  • Drug Interactions
  • Female
  • Graft Rejection / blood*
  • Graft Rejection / drug therapy
  • Humans
  • Liver Transplantation* / statistics & numerical data
  • Middle Aged
  • Phenytoin / pharmacokinetics*
  • Phenytoin / therapeutic use
  • Sirolimus / blood*
  • Sirolimus / therapeutic use

Substances

  • Phenytoin
  • Sirolimus