Intra-erythrocyte deposition of growth hormone in rheumatic diseases

Rheumatol Int. 2003 Jan;23(1):11-4. doi: 10.1007/s00296-002-0245-4. Epub 2002 Sep 11.


Standard radioimmunoassay was employed to quantify matched basal intra-erythrocyte growth hormone (GH) and serum GH levels from patients with osteoarthritis, diffuse idiopathic skeletal hyperostosis (DISH), gout, and Sjögren's syndrome and in a group of normal volunteers (control group). Basal intra-erythrocyte GH concentration was significantly higher ( P<0.05) than serum GH concentration in blood samples from patients with osteoarthritis and DISH but not from those with gout or Sjögren's syndrome. Regression analysis determined that basal serum GH levels did not correlate with age. While intra-erythrocyte GH levels exceeded serum GH levels in osteoarthritis and DISH, intra-erythrocyte GH was not a strong predictor of serum GH levels in osteoarthritis, DISH, or in the control group.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Analysis of Variance
  • Biomarkers / analysis
  • Case-Control Studies
  • Erythrocytes / metabolism*
  • Female
  • Gout / blood
  • Gout / physiopathology
  • Human Growth Hormone / analysis
  • Human Growth Hormone / metabolism*
  • Humans
  • Hyperostosis, Diffuse Idiopathic Skeletal / blood
  • Hyperostosis, Diffuse Idiopathic Skeletal / physiopathology
  • Male
  • Middle Aged
  • Osteoarthritis / blood
  • Osteoarthritis / physiopathology
  • Probability
  • Radioimmunoassay
  • Reference Values
  • Regression Analysis
  • Rheumatic Diseases / blood*
  • Rheumatic Diseases / physiopathology
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Sjogren's Syndrome / blood
  • Sjogren's Syndrome / physiopathology


  • Biomarkers
  • Human Growth Hormone