Expanding the organismal scope of proteomics: cross-species protein identification by mass spectrometry and its implications

Proteomics. 2003 Jan;3(1):19-28. doi: 10.1002/pmic.200390004.


Due to the limited applicability of conventional protein identification methods to the proteomes of organisms with unsequenced genomes, researchers have developed approaches to identify proteins using mass spectrometry and sequence similarity database searches. Both the integration of mass spectrometry with bioinformatics and genomic sequencing drive the expanding organismal scope of proteomics.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Computational Biology
  • Databases, Protein
  • Genomics
  • Humans
  • Mass Spectrometry / methods*
  • Phylogeny
  • Proteins / genetics*
  • Proteins / isolation & purification*
  • Proteomics / methods*
  • Proteomics / statistics & numerical data
  • Proteomics / trends
  • Sequence Alignment
  • Species Specificity


  • Proteins