Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora

Angew Chem Int Ed Engl. 2003 Jan 20;42(3):355-7. doi: 10.1002/anie.200390115.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actinomycetales / chemistry*
  • Actinomycetales / classification
  • Adenocarcinoma / metabolism
  • Colonic Neoplasms / metabolism
  • Crystallography, X-Ray
  • Cysteine Endopeptidases
  • Humans
  • Inhibitory Concentration 50
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Structure
  • Multienzyme Complexes / antagonists & inhibitors*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / isolation & purification
  • Protease Inhibitors / pharmacology*
  • Proteasome Endopeptidase Complex
  • Pyrroles
  • Tumor Cells, Cultured

Substances

  • Lactones
  • Multienzyme Complexes
  • Protease Inhibitors
  • Pyrroles
  • marizomib
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex