99mTc-tetrofosmin or 99mTc-sestamibi for double-phase parathyroid scintigraphy?

Eur J Nucl Med Mol Imaging. 2003 Feb;30(2):193-6. doi: 10.1007/s00259-002-1030-z. Epub 2002 Nov 23.


Several years ago technetium-99m tetrofosmin was reported to localise parathyroid adenomas. The aim of this study was to compare the sensitivity of this radiopharmaceutical with that of (99m)Tc-sestamibi using a double-phase parathyroid scintigraphy protocol. Scans of 12 patients were evaluated visually and lesion to thyroid ratios were calculated. Nine of the patients were subsequently operated on; a total of eight parathyroid adenomas or hyperplastic glands were histologically confirmed in seven of the patients, while in one patient a parathyroid carcinoma was histologically proven. All of these patients had positive (99m)Tc-sestamibi scintigrams, whereas only two (99m)Tc-tetrofosmin scintigrams were positive. With (99m)Tc-sestamibi there was a significant increase in the lesion to thyroid ratio from 10 min to 90 min and 150 min p.i. which was not seen on scintigraphy with (99m)Tc-tetrofosmin. This makes (99m)Tc-tetrofosmin less suitable for double-phase parathyroid scintigraphy.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adenoma / complications
  • Adenoma / diagnostic imaging*
  • Adenoma / pathology
  • Female
  • Humans
  • Hyperparathyroidism / diagnostic imaging
  • Hyperparathyroidism / etiology
  • Hyperparathyroidism / pathology
  • Male
  • Middle Aged
  • Organophosphorus Compounds*
  • Organotechnetium Compounds*
  • Parathyroid Glands / diagnostic imaging
  • Parathyroid Glands / pathology
  • Parathyroid Neoplasms / complications
  • Parathyroid Neoplasms / diagnostic imaging*
  • Parathyroid Neoplasms / pathology
  • Predictive Value of Tests
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Single-Blind Method
  • Technetium Tc 99m Sestamibi*


  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium tc-99m tetrofosmin
  • Technetium Tc 99m Sestamibi