Predictive value of CD8highCD57+ lymphocyte subset in interferon therapy of patients with renal cell carcinoma

Anticancer Res. Nov-Dec 2002;22(6B):3679-83.

Abstract

Background: The aim of this retrospective study was to evaluate the significance of pre-treatment levels of peripheral blood lymphocyte subsets for survival of renal cell carcinoma (RCC) patients treated with interferon-a2b (IFN).

Patients and methods: CD3+, CD19+, CD16&56+, CD4+, CD8+, CD4+CD45ROhigh and CD8highCD57+ lymphocyte subsets in peripheral blood of 85 advanced RCC patients were determined using flow cytometry. The survival of IFN-treated and non-treated patients was analyzed by gradually testing different cut-off levels of each lymphocyte subset.

Results: Advanced RCC patients with > or = 30% CD8highCD57+ lymphocytes in the CD8+ subset had shorter survival compared to patients with < 30% CD8highCD57+ lymphocytes in the CD8+ subset (p = 0.01). Treatment with IFN increased overall survival only in the former subgroup of RCC patients (p = 0.02).

Conclusion: The present study suggests that the percentage of CD8highCD57+ lymphocytes in the CD8+ subset may have a prognostic significance for advanced RCC patients and may have a predictive value in patient selection for survival benefit due to treatment with IFN.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • CD4-CD8 Ratio
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology
  • CD57 Antigens / immunology*
  • CD8-Positive T-Lymphocytes / cytology
  • CD8-Positive T-Lymphocytes / immunology*
  • Carcinoma, Renal Cell / blood
  • Carcinoma, Renal Cell / drug therapy
  • Carcinoma, Renal Cell / immunology*
  • Female
  • Fluorouracil / administration & dosage
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage
  • Interferon-alpha / therapeutic use*
  • Kidney Neoplasms / blood
  • Kidney Neoplasms / drug therapy
  • Kidney Neoplasms / immunology*
  • Lymphocyte Subsets / immunology*
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Recombinant Proteins
  • Retrospective Studies

Substances

  • CD57 Antigens
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Fluorouracil