p63 expression profile in normal and malignant prostate epithelial cells

Anticancer Res. Nov-Dec 2002;22(6C):3819-25.

Abstract

p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Biomarkers, Tumor / biosynthesis
  • Biomarkers, Tumor / genetics
  • DNA-Binding Proteins
  • Epithelial Cells / metabolism
  • Epithelial Cells / physiology
  • Genes, Tumor Suppressor
  • Humans
  • Immunohistochemistry
  • Male
  • Membrane Proteins*
  • Middle Aged
  • Neoplasm Staging
  • Phosphoproteins / biosynthesis*
  • Phosphoproteins / genetics
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Trans-Activators / biosynthesis*
  • Trans-Activators / genetics
  • Transcription Factors
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins

Substances

  • Biomarkers, Tumor
  • CKAP4 protein, human
  • DNA-Binding Proteins
  • Membrane Proteins
  • Phosphoproteins
  • TP63 protein, human
  • Trans-Activators
  • Transcription Factors
  • Tumor Suppressor Proteins