Endosome-specific Localization and Function of the ARF Activator GNOM

Cell. 2003 Jan 24;112(2):141-2. doi: 10.1016/s0092-8674(03)00038-2.


ARF GTPases act at multiple steps of the secretory and vacuolar/lysosomal trafficking pathways, but little is known about the spatial regulation of ARF activation. In this issue of Cell, Geldner et al. demonstrate that the Arabidopsis ARF activator GNOM localizes to endosomes where it controls the polarized trafficking of the auxin efflux carrier PIN1 to the basal plasma membrane.

Publication types

  • Comment

MeSH terms

  • Arabidopsis / cytology*
  • Arabidopsis / genetics
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism*
  • Biological Transport, Active
  • Endosomes / metabolism*
  • Guanine Nucleotide Exchange Factors*
  • Indoleacetic Acids / metabolism*
  • Membrane Proteins / metabolism
  • Membrane Transport Proteins*
  • Plant Growth Regulators / genetics
  • Plant Growth Regulators / metabolism*


  • Arabidopsis Proteins
  • GNOM protein, Arabidopsis
  • Guanine Nucleotide Exchange Factors
  • Indoleacetic Acids
  • Membrane Proteins
  • Membrane Transport Proteins
  • PIN1 protein, Arabidopsis
  • Plant Growth Regulators