A forty-year memoir of research on the regulation of glucose transport into muscle

Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E453-67. doi: 10.1152/ajpendo.00463.2002.


This historical review describes the research on the regulation of glucose transport in skeletal muscle conducted in my laboratory and in collaboration with a number of colleagues in other laboratories. This research includes studies of stimulation of glucose transport, GLUT4 translocation, and GLUT4 expression by exercise/muscle contractions, the role of Ca(2+) in these processes, and the interactions between the effects of exercise and insulin. Among the last are the additive effects of insulin and contractions on glucose transport and GLUT4 translocation and the increases in muscle insulin sensitivity and responsiveness induced by exercise.

Publication types

  • Autobiography
  • Biography
  • Historical Article
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Calcium / metabolism
  • Glucose / metabolism*
  • Glucose Transporter Type 4
  • History, 20th Century
  • Humans
  • Insulin / metabolism
  • Monosaccharide Transport Proteins / metabolism
  • Motor Activity / physiology
  • Muscle Proteins*
  • Muscle, Skeletal / metabolism*
  • Physiology / history
  • Physiology / trends
  • United States


  • Glucose Transporter Type 4
  • Insulin
  • Monosaccharide Transport Proteins
  • Muscle Proteins
  • SLC2A4 protein, human
  • Glucose
  • Calcium

Personal name as subject

  • John O Holloszy