The successful clone: the vector of dissemination of resistance in Streptococcus pneumoniae

J Antimicrob Chemother. 2002 Dec;50 Suppl S2:1-5. doi: 10.1093/jac/dkf500.


A small number of pneumococcal clones dominate the population of antibiotic-resistant pneumococci. The emergence of fluoroquinolone resistance in these clones predicts the dissemination of fluoroquinolone resistance in countries where the clones are present and community use of fluoroquinolones for respiratory infections is common. The molecular basis of resistance to a number of classes of antimicrobials can be used to predict the likelihood of dissemination of the resistance genes.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology
  • Anti-Infective Agents / therapeutic use
  • Clone Cells / drug effects
  • Clone Cells / physiology
  • Drug Resistance, Bacterial / genetics*
  • Fluoroquinolones
  • Genetic Vectors / genetics*
  • Humans
  • Point Mutation / drug effects
  • Point Mutation / genetics
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pneumoniae / genetics*


  • Anti-Infective Agents
  • Fluoroquinolones