Effect of Alcohol Extract of Achyranthes Aspera Linn. On Acute and Subacute Inflammation

Phytother Res. 2003 Jan;17(1):77-9. doi: 10.1002/ptr.1070.

Abstract

The antiinflammatory activity of an alcohol extract of Achyranthes aspera was tested on carrageenin-induced hind paw oedema and cotton pellet granuloma models in albino male rats. The paw volume was measured plethysmometrically at 0, 1, 2, 3, 4 and 5 h. In the subacute model cotton pellet granuloma was produced by implantation of 50 +/- 1 mg sterile cotton in the axilla under ether anaesthesia. The animals were fed with an alcohol extract at various dose levels (125, 250, 375 and 500 mg/kg). Diclofenac sodium was used as a standard drug. The alcohol extract (375 and 500 mg/kg) showed the maximum inhibition of oedema of 65.38% and 72.37% at the end of 3 h with carrageenin-induced rat paw oedema, respectively. Using a chronic test, the extract exhibited a 40.03% and 45.32% reduction in granuloma weight.

MeSH terms

  • Achyranthes*
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Carrageenan
  • Diclofenac / pharmacology
  • Dose-Response Relationship, Drug
  • Edema / chemically induced
  • Edema / pathology
  • Edema / prevention & control*
  • Granuloma / chemically induced
  • Granuloma / prevention & control*
  • Male
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Rats
  • Severity of Illness Index

Substances

  • Anti-Inflammatory Agents
  • Plant Extracts
  • Diclofenac
  • Carrageenan