Topical application of NADH for the treatment of rosacea and contact dermatitis

Clin Exp Dermatol. 2003 Jan;28(1):61-3. doi: 10.1046/j.1365-2230.2003.01118.x.


Among many important physiological functions played by NADH (the reduced form of beta-nicotinamide adenine dinucleotide) its antioxidative properties are remarkable. Acting directly as an antioxidant, NADH can effectively protect the cell and its membrane from destruction by free radicals. NADH can be stabilized as a suspension in hydrophobic ointments prepared in a way that prevents contact with atmosphere containing oxygen and water. We present the first report of NADH as a treatment for some inflammatory dermatoses. It was found that topical application of 1% NADH diluted in Vaseline ointment can be very effective in the treatment of rosacea and contact dermatitis. Since no adverse effects were observed, therapy with NADH can be viewed as a potential alternative to other established treatments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arm
  • Dermatitis, Allergic Contact / drug therapy*
  • Dermatitis, Allergic Contact / pathology
  • Dermatitis, Contact / drug therapy*
  • Dermatitis, Contact / pathology
  • Facial Dermatoses / drug therapy
  • Facial Dermatoses / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • NAD / administration & dosage*
  • Ointments
  • Rosacea / drug therapy*
  • Rosacea / pathology


  • Ointments
  • NAD