Effect of anatomic, procedural, and dosimetric variables on urinary retention after permanent iodine-125 prostate brachytherapy

Urology. 2003 Jan;61(1):152-5. doi: 10.1016/s0090-4295(02)02142-8.

Abstract

Objectives: To correlate anatomic, procedural, and dosimetric parameters with the rate of intermittent self-catheterization (ISC).

Methods: The records of 402 patients with a median age of 69 years treated with 125I prostate seed implantation from 1996 to 2001 were reviewed for the use of ISC. The records were examined for the preimplant factors: prostate volume, use of androgen deprivation, and prostate length. The intraprocedural factor reviewed was the number of needles used. The following postimplant information was also collected: preimplant transrectal ultrasound-generated prostate volume/postimplant computed tomography-generated prostate volume ratio, V100, V150, V200, V300, V400, D90, and D100. Correlation was assessed using logistic regression analysis.

Results: Forty-four patients had to use ISC (10.9%). The mean and median duration of ISC was 11.9 and 6 weeks, respectively. From univariate analysis, prostate length and prostate volume were found to be statistically significant predictors of ISC after 125I prostate seed implantation with a P value of 0.0002 and 0.0042, respectively. With multivariate analysis, only prostate length was a statistically significant predictor of ISC use after 125I prostate seed implantation (P = 0.0095).

Conclusions: Prostate length is an important predictor of ISC after 125I prostate seed implantation.

MeSH terms

  • Aged
  • Brachytherapy / adverse effects*
  • Humans
  • Iodine Radioisotopes / adverse effects
  • Iodine Radioisotopes / therapeutic use
  • Male
  • Prostate / anatomy & histology
  • Prostate / diagnostic imaging*
  • Prostate / pathology
  • Prostatic Neoplasms / diagnostic imaging
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / radiotherapy*
  • Radiotherapy Dosage
  • Regression Analysis
  • Retrospective Studies
  • Risk Factors
  • Self Care / statistics & numerical data
  • Ultrasonography
  • Urinary Catheterization / statistics & numerical data
  • Urinary Retention / etiology*
  • Urinary Retention / therapy*

Substances

  • Iodine Radioisotopes