Remyelination in multiple sclerosis

J Neurol Sci. 2003 Feb 15;206(2):181-5. doi: 10.1016/s0022-510x(02)00191-0.


Remyelination in multiple sclerosis (MS) lesions has been described in several studies. It depends on the presence of myelinating oligodendrocytes and a functional interaction between these myelinating cells and axons. The imaging signal of remyelination in magnetic resonance imaging or spectroscopy is not yet defined. The present review will focus on the morphological appearance of remyelinating MS lesions, their correlation with oligodendrocyte pathology, and possible markers for remyelination in imaging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / pathology
  • Central Nervous System / pathology
  • Central Nervous System / physiopathology
  • Humans
  • Magnetic Resonance Imaging / methods
  • Multiple Sclerosis / physiopathology*
  • Multiple Sclerosis / therapy
  • Myelin Sheath / pathology
  • Oligodendroglia / pathology
  • Rats
  • Regeneration