Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

Trends Cell Biol. 2003 Feb;13(2):71-8. doi: 10.1016/s0962-8924(02)00041-7.

Abstract

This review summarizes recent findings and common principles for intramembrane-cleaving proteases that catalyse critical steps in cell regulation and signalling and which are involved in diseases such as Alzheimer's disease and hepatitis C virus infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Catalytic Domain / physiology
  • Cell Membrane / enzymology*
  • Endopeptidases / metabolism*
  • Eukaryotic Cells / enzymology*
  • Humans
  • Hydrolysis
  • Intracellular Membranes / enzymology*
  • Membrane Proteins / metabolism
  • Metalloendopeptidases / metabolism
  • Peptides / metabolism*
  • Presenilin-1

Substances

  • Membrane Proteins
  • PSEN1 protein, human
  • Peptides
  • Presenilin-1
  • Endopeptidases
  • Metalloendopeptidases
  • MBTPS2 protein, human