Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family

Trends Pharmacol Sci. 2003 Feb;24(2):52-5. doi: 10.1016/S0165-6147(02)00038-X.


The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently. This receptor has important structural similarities to known members of the P2Y receptor family but also shows a distinctly different pharmacological response profile. Here, the IUPHAR Subcommittee for P2Y receptor nomenclature and classification review the current knowledge of this receptor and present their reasons for including this receptor in the P2Y receptor family as the P2Y(14) receptor.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites / physiology
  • Humans
  • Receptors, G-Protein-Coupled*
  • Receptors, Purinergic P2 / chemistry
  • Receptors, Purinergic P2 / genetics
  • Receptors, Purinergic P2 / metabolism*
  • Receptors, Purinergic P2Y
  • Uridine Diphosphate Glucose / metabolism*


  • P2RY14 protein, human
  • Receptors, G-Protein-Coupled
  • Receptors, Purinergic P2
  • Receptors, Purinergic P2Y
  • Uridine Diphosphate Glucose