Primary brain tumours in adults

Lancet. 2003 Jan 25;361(9354):323-31. doi: 10.1016/S0140-6736(03)12328-8.


The most frequent primary brain tumours in adults are gliomas and primary CNS lymphomas. In gliomas, molecular genetic analysis plays an increasing part in classification and treatment planning, a feature well illustrated by the chemosensitive oligodendrogliomas. Unfortunately, management of glioblastoma is still mainly palliative. Incidence of primary CNS lymphoma has increased strikingly in the past 20 years; substantial progress has been achieved in patients who are immunocompetent with the addition of methotrexate-based chemotherapy to radiotherapy, but the potential neurotoxic effects of this combination in elderly patients is worrisome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Brain Neoplasms* / classification
  • Brain Neoplasms* / diagnosis
  • Brain Neoplasms* / genetics
  • Brain Neoplasms* / physiopathology
  • Combined Modality Therapy
  • Glioma* / classification
  • Glioma* / diagnosis
  • Glioma* / genetics
  • Glioma* / physiopathology
  • Humans
  • Magnetic Resonance Imaging
  • Molecular Biology