Successful treatment of intractable hiccup with methylphenidate in a lung cancer patient

Support Care Cancer. 2003 Feb;11(2):126-8. doi: 10.1007/s00520-002-0411-y. Epub 2002 Dec 7.


In a 56-year-old man with metastatic small-cell lung cancer, a persistent hiccup was refractory to classic treatments. Hyponatremia, neoplasic mediastinal involvement and liver metastases were though to be potential causative factors. Methylphenidate (MTP), a mild central nervous system (CNS) stimulant that is most commonly used for the treatment of attention deficit hyperactivity disorder, was started at a daily dose of 10 mg. It was rapidly efficient and well tolerated. This report suggests a potential advantage of MTP in the treatment of intractable hiccup in cancer patients.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Small Cell / complications*
  • Central Nervous System Stimulants / pharmacology*
  • Hiccup / drug therapy*
  • Hiccup / etiology*
  • Humans
  • Lung Neoplasms / complications*
  • Male
  • Methylphenidate / pharmacology*
  • Middle Aged


  • Central Nervous System Stimulants
  • Methylphenidate