Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism

J Surg Oncol. 2003 Feb;82(2):132-6; disccussion 137. doi: 10.1002/jso.10181.

Abstract

The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed overexpression of BMP-2 by the tumor cells, elucidating a possible mechanism which up to now had been based merely on speculation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / complications*
  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy
  • Adult
  • Antimetabolites, Antineoplastic / therapeutic use
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins / metabolism*
  • Colectomy
  • Enzyme Inhibitors / therapeutic use
  • Female
  • Fibroblast Growth Factor 2 / metabolism*
  • Fluorouracil / therapeutic use
  • Humans
  • Immunohistochemistry
  • Neoadjuvant Therapy
  • Ossification, Heterotopic / etiology*
  • Ossification, Heterotopic / metabolism*
  • Radiotherapy, Adjuvant
  • Rectal Neoplasms / complications*
  • Rectal Neoplasms / metabolism*
  • Rectal Neoplasms / pathology
  • Rectal Neoplasms / therapy
  • Transforming Growth Factor beta*
  • Treatment Outcome
  • Uracil / analogs & derivatives*
  • Uracil / therapeutic use

Substances

  • Antimetabolites, Antineoplastic
  • BMP2 protein, human
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins
  • Enzyme Inhibitors
  • Transforming Growth Factor beta
  • Fibroblast Growth Factor 2
  • eniluracil
  • Uracil
  • Fluorouracil