Abstract
The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed overexpression of BMP-2 by the tumor cells, elucidating a possible mechanism which up to now had been based merely on speculation.
Copyright 2003 Wiley-Liss, Inc.
MeSH terms
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Adenocarcinoma / complications*
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Adenocarcinoma / metabolism*
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Adenocarcinoma / pathology
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Adenocarcinoma / therapy
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Adult
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Antimetabolites, Antineoplastic / therapeutic use
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Bone Morphogenetic Protein 2
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Bone Morphogenetic Proteins / metabolism*
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Colectomy
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Enzyme Inhibitors / therapeutic use
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Female
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Fibroblast Growth Factor 2 / metabolism*
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Fluorouracil / therapeutic use
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Humans
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Immunohistochemistry
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Neoadjuvant Therapy
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Ossification, Heterotopic / etiology*
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Ossification, Heterotopic / metabolism*
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Radiotherapy, Adjuvant
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Rectal Neoplasms / complications*
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Rectal Neoplasms / metabolism*
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Rectal Neoplasms / pathology
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Rectal Neoplasms / therapy
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Transforming Growth Factor beta*
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Treatment Outcome
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Uracil / analogs & derivatives*
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Uracil / therapeutic use
Substances
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Antimetabolites, Antineoplastic
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BMP2 protein, human
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Bone Morphogenetic Protein 2
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Bone Morphogenetic Proteins
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Enzyme Inhibitors
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Transforming Growth Factor beta
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Fibroblast Growth Factor 2
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eniluracil
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Uracil
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Fluorouracil