[Inhibition the growth of human leukemia cells by Lycium barbarum polysaccharide]

Wei Sheng Yan Jiu. 2001 Nov;30(6):333-5.
[Article in Chinese]


The effect and the mechanism of Lycium barbarum polysaccharide (LBP-X) on inhibiting the growth of human leukemia HL-60 cells were examined. LBP-X(20, 100, 500, 1000 mg/L) could inhibit the growth of HL-60 cells in dose-dependent manner and decrease the membrane fluidity of the cell. Agarose gel electrophoresis of DNA from the cells treated with LBP-X revealed a "DNA ladder" and positive TUNEL test. The results showed that the apoptosis of HL-60 cells induced by LBP-X maybe its important mechanism on anti-tumorgenesis.

Publication types

  • English Abstract

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apoptosis / drug effects*
  • Cell Division / drug effects
  • HL-60 Cells / cytology
  • Humans
  • Lycium / chemistry*
  • Polysaccharides / pharmacology*


  • Antineoplastic Agents, Phytogenic
  • Polysaccharides