Bactericidal activity of daptomycin against Streptococcus pneumoniae compared with eight other antimicrobials

J Antimicrob Chemother. 2003 Feb;51(2):443-6. doi: 10.1093/jac/dkg091.


A spectrum of pneumococci with varying susceptibilities to beta-lactams, macrolides and quinolones was tested for susceptibility to nine antibiotics, including the novel lipopeptide daptomycin. Daptomycin was active against all strains (MIC range </=0.5 mg/L; MIC(50) 0.125 mg/L; MIC(90) 0.25 mg/L). All pneumococci were susceptible to vancomycin, teicoplanin, linezolid and quinupristin/dalfopristin, with MICs < 4.0 mg/L. Time-kill assays with eight strains demonstrated that daptomycin (2 x MIC) was bactericidal in seven of eight strains tested at 24 h, with >90% killing at 1 h.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Quinolones
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Infective Agents / pharmacology
  • Daptomycin / pharmacology*
  • Lactams
  • Macrolides
  • Microbial Sensitivity Tests
  • Penicillin Resistance
  • Streptococcus pneumoniae / drug effects*
  • Time Factors


  • 4-Quinolones
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Lactams
  • Macrolides
  • Daptomycin