Abstract
We identified a tri-cistronic operon, gerH, in Bacillus anthracis that is important for endospore germination triggered by two distinct germination response pathways termed inosine-His and purine-Ala. Together, the two pathways allow B. anthracis endospores a broader recognition of purines and amino acids that may be important for host-mediated germination.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alanine / pharmacology
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Amino Acids / pharmacology
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Bacillus anthracis / genetics
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Bacillus anthracis / physiology*
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Inosine / pharmacology
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Operon*
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Purine Nucleosides / pharmacology*
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Spores, Bacterial / genetics
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Spores, Bacterial / physiology
Substances
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Amino Acids
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Bacterial Proteins
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Purine Nucleosides
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Inosine
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Alanine