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, 4 (3), 225-34

Lineage Relationship and Protective Immunity of Memory CD8 T Cell Subsets

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Lineage Relationship and Protective Immunity of Memory CD8 T Cell Subsets

E John Wherry et al. Nat Immunol.

Abstract

Memory CD8 T cells can be divided into two subsets, central (T(CM)) and effector (T(EM)), but their lineage relationships and their ability to persist and confer protective immunity are not well understood. Our results show that T(CM) have a greater capacity than T(EM) to persist in vivo and are more efficient in mediating protective immunity because of their increased proliferative potential. We also demonstrate that, following antigen clearance, T(EM) convert to T(CM) and that the duration of this differentiation is programmed within the first week after immunization. We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway.

Comment in

  • Memory Lanes
    VP Badovinac et al. Nat Immunol 4 (3), 212-3. PMID 12605228.

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