The role of p53 in determining sensitivity to radiotherapy

Nat Rev Cancer. 2003 Feb;3(2):117-29. doi: 10.1038/nrc992.


Ionizing radiation (IR) has proven to be a powerful medical treatment in the fight against cancer. Rational and effective use of its killing power depends on understanding IR-mediated responses at the molecular, cellular and tissue levels. Tumour cells frequently acquire defects in the molecular regulatory mechanisms of the response to IR, which sensitizes them to radiation therapy. One of the key molecules involved in a cell's response to IR is p53. Understanding these mechanisms indicates new rational approaches to improving cancer treatment by IR.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Humans
  • Neoplasms / radiotherapy*
  • Radiation Tolerance*
  • Tumor Suppressor Protein p53* / physiology*


  • Tumor Suppressor Protein p53