Exp Eye Res. 2003 Feb;76(2):145-53. doi: 10.1016/s0014-4835(02)00278-6.


Alpha A and alpha B-crystallins are a major protein component of the mammalian eye lens. Being a member of the small heat-shock protein family they possess chaperone-like function. The alpha-crystallins and especially alpha B is also found outside the lens having an extensive tissue distribution. Alpha B-crystallin is found to be over-expressed in many neurological diseases, and mutations in alpha A or B-crystallin can cause cataract and myopathy. This review deals with some of the unique properties of the alpha-crystallins emphasizing especially what we don't know about its function and structure.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cataract / genetics
  • Humans
  • Mice
  • Mice, Knockout
  • Mutation
  • Phosphorylation
  • Protein Structure, Quaternary
  • alpha-Crystallins / chemistry
  • alpha-Crystallins / genetics
  • alpha-Crystallins / physiology*


  • alpha-Crystallins