Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging

Neurosci Lett. 2003 Feb 27;338(2):119-22. doi: 10.1016/s0304-3940(02)01367-8.


To assess the usefulness of perfusion-weighted echo-planar magnetic resonance imaging in the differential diagnosis of primary supratentorial lymphoma (PCNSL) and glioblastoma (GBM), 12 patients with a PCNSL and 12 with a GBM were examined using a 1.5 T magnetic resonance (MR) imager. With dynamic-susceptibility contrast MR imaging the intensity-time curves of each tumor were analyzed, and we determined the relative regional cerebral blood volume ratios (rrCBV [tumor/contralateral white matter (WM)]) to find out whether these parameters could be used to separate PCNSL from GBM. The maximum rrCBV ratio in the PCNSL was significantly lower than that of the GBM (P<0.0001). Comparing the intensity-time curves for the two tumor groups, the PCNSL showed a characteristic type of curve with a significant increase in signal intensity above the baseline due to massive leakage of contrast media into the interstitial space. PCNSL tend to have low maximum CBV ratios and typical intensity-time curves. These two parameters may be useful in distinguishing PCNSL from GBM.

MeSH terms

  • Brain Neoplasms / blood supply
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / pathology
  • Diagnosis, Differential
  • Glioma / blood supply
  • Glioma / diagnosis*
  • Glioma / pathology
  • Humans
  • Lymphoma / diagnosis*
  • Lymphoma / pathology
  • Magnetic Resonance Imaging / methods
  • Severity of Illness Index
  • Supratentorial Neoplasms / blood supply
  • Supratentorial Neoplasms / diagnosis
  • Supratentorial Neoplasms / pathology