Fluoride concentration in saliva after use of oral hygiene products

Caries Res. Jan-Feb 2003;37(1):66-70. doi: 10.1159/000068220.


The purpose of this in vivo, single-blind, randomized study was to compare fluoride concentrations in saliva of patients treated with oral hygiene products containing different fluoride salts. The study involved 104 students attending the University of Sassari. Participants were subdivided: group A used a sodium monofluorophosphate (NaMFP) toothpaste; groups B and C used an amine fluoride (AmF) toothpaste; group D used a toothpaste and a mouthwash both based on AmF, and group E used a toothpaste and a varnish both on an NaMFP base. Samples of unstimulated saliva were collected at baseline (t(0)), at the end of the 20 days' treatment phase (t(1)) and after 24 h, during which the volunteers refrained from any oral hygiene measure (t(2)). Saliva fluoride concentrations were measured using an ion-specific electrode. All measurements were made in triplicate and analysed statistically using ANOVA. In saliva, the mean fluoride concentration increased significantly in each treatment group. In conclusion, the fluoride concentration in saliva can be maintained to an optimal therapeutic level with the regular use of fluoridated products.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amines / pharmacokinetics
  • Amines / therapeutic use
  • Analysis of Variance
  • Cariostatic Agents / pharmacokinetics*
  • Cariostatic Agents / therapeutic use
  • Dentifrices / chemistry*
  • Female
  • Fluorides / pharmacokinetics*
  • Fluorides / therapeutic use
  • Fluorides, Topical / pharmacokinetics
  • Fluorides, Topical / therapeutic use
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Mouthwashes / chemistry*
  • Paint
  • Phosphates / pharmacokinetics
  • Phosphates / therapeutic use
  • Saliva / metabolism
  • Single-Blind Method
  • Tin Fluorides / pharmacokinetics
  • Tin Fluorides / therapeutic use


  • Amines
  • Cariostatic Agents
  • Dentifrices
  • Fluorides, Topical
  • Mouthwashes
  • Phosphates
  • Tin Fluorides
  • amine fluoride solution
  • fluorophosphate
  • amine fluoride gel
  • Fluorides