Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia

Horm Res. 2003;59(1):30-4. doi: 10.1159/000067933.

Abstract

Aim: The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated.

Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined.

Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level.

Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.

MeSH terms

  • Adrenomedullin
  • Adult
  • Aged
  • Anesthesia, General*
  • Aquaporin 2
  • Aquaporin 6
  • Aquaporins / urine*
  • Arginine Vasopressin / blood*
  • Creatinine / urine
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peptides / blood*
  • Time Factors

Substances

  • AQP2 protein, human
  • Aquaporin 2
  • Aquaporin 6
  • Aquaporins
  • Peptides
  • Arginine Vasopressin
  • Adrenomedullin
  • Creatinine