Role of serine/threonine protein phosphatase in Alzheimer's disease

Neurosignals. Sep-Oct 2002;11(5):262-9. doi: 10.1159/000067425.


Accumulating evidence indicates that serine/threonine (Ser/Thr) protein phosphatases (PPs), such as PP1, PP2A and PP2B, participate in the neurodegenerative progress in Alzheimer's disease (AD). The general characteristics and pathologic changes of PP1, PP2A and PP2B in AD, and their relations with microtubule-associated proteins, focusing mainly on tau protein, neurofilament (NF), amyloid precursor protein (APP) processing and synaptic plasticity are discussed. Deriving novel insight into the particular topic will attract greater attention to more active investigation and effective therapeutic intervention in the future.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / pathology
  • Neuronal Plasticity
  • Phosphoprotein Phosphatases / metabolism*
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Substrate Specificity


  • Amyloid beta-Peptides
  • Microtubule-Associated Proteins
  • Phosphoprotein Phosphatases