Hyperhomocystinemia in pseudoexfoliation glaucoma

J Glaucoma. 2003 Feb;12(1):36-9. doi: 10.1097/00061198-200302000-00007.


Purpose: To determine the prevalence of hyperhomocystinemia in patients with pseudoexfoliation glaucoma.

Patients and methods: This prospective study included 30 patients with glaucoma and 30 age-matched controls with no history of ocular disease who were undergoing routine physical checkups. Plasma homocysteine levels of all the study participants were determined using high-performance liquid chromatography, and values exceeding 15 micromol/L were considered elevated.

Results: The mean plasma homocysteine level was 16.80 +/- 3.20 and 12.39 +/- 1.97 micromol/L in glaucoma patients and controls, respectively (P<0.0001). Fifteen glaucoma patients (50%) had hyperhomocystinemia compared with 3 controls (10%) (P=0.0015).

Conclusion: Hyperhomocystinemia may be associated with pseudoexfoliation glaucoma, which may partially explain the increased risk of vascular diseases among patients with pseudoexfoliation syndrome.

MeSH terms

  • Aged
  • Chromatography, High Pressure Liquid
  • Exfoliation Syndrome / blood
  • Exfoliation Syndrome / complications*
  • Female
  • Glaucoma, Open-Angle / blood
  • Glaucoma, Open-Angle / complications*
  • Homocysteine / blood
  • Humans
  • Hyperhomocysteinemia / blood
  • Hyperhomocysteinemia / etiology*
  • Male
  • Prevalence
  • Prospective Studies


  • Homocysteine