VIP and Drug Design

Curr Pharm Des. 2003;9(6):483-94. doi: 10.2174/1381612033391667.

Abstract

The following review outlines the physiological outcome of VIP and VIP gene manipulations. Previously, we reviewed the various VIP receptors associated with biological functions ranging from growth regulation, sexual function, bronchodilation, vasodilation and immune interactions to neurotrophism. VIP-based drug design is discussed below.

Publication types

  • Review

MeSH terms

  • Animals
  • Bronchi / drug effects
  • Bronchodilator Agents / therapeutic use
  • Circadian Rhythm / drug effects
  • Drug Design*
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Knockout
  • Neuropeptides / physiology
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Prostatic Neoplasms / drug therapy
  • Rats
  • Receptors, Vasoactive Intestinal Peptide / agonists
  • Receptors, Vasoactive Intestinal Peptide / antagonists & inhibitors
  • Receptors, Vasoactive Intestinal Peptide / physiology*
  • Sexual Dysfunction, Physiological / drug therapy
  • Signal Transduction / drug effects*
  • Signal Transduction / genetics
  • Vasoactive Intestinal Peptide / pharmacology*
  • Vasoactive Intestinal Peptide / therapeutic use

Substances

  • ADCYAP1 protein, human
  • Adcyap1 protein, mouse
  • Adcyap1 protein, rat
  • Bronchodilator Agents
  • Neuropeptides
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Receptors, Vasoactive Intestinal Peptide
  • Vasoactive Intestinal Peptide