Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
, 25 (2), 169-72

Refractory Iron Deficiency Anemia as the Primary Clinical Manifestation of Celiac Disease

Case Reports

Refractory Iron Deficiency Anemia as the Primary Clinical Manifestation of Celiac Disease

Rajen J Mody et al. J Pediatr Hematol Oncol.


In the absence of dietary insufficiency, iron deficiency is usually caused by chronic blood loss or intestinal malabsorption. Celiac disease is one of the most common causes of intestinal malabsorption during childhood, and its association with insulin-dependent diabetes mellitus has been previously reported. Here the authors describe an otherwise asymptomatic diabetic adolescent boy with iron deficiency anemia that was not responsive to oral iron therapy. A diagnosis of celiac disease was made based on both anti-endomysial antibody titers and small intestinal biopsy. Institution of a gluten-free diet resulted in correction of the anemia. These observations emphasize the importance of considering a diagnosis of celiac disease in patients with nonresponsive iron deficiency anemia, particularly in the setting of insulin-dependent diabetes mellitus.

Comment in

Similar articles

  • Anemia and Iron Deficiency in Children With Potential Celiac Disease
    M Repo et al. J Pediatr Gastroenterol Nutr 64 (1), 56-62. PMID 27101536.
    The development of anemia and iron deficiency in celiac disease is a continuum and may already be present in children with normal villous morphology, advocating an early …
  • The Prevalence of Celiac Disease in Children With Iron-Deficiency Anemia
    V Ertekin et al. Turk J Gastroenterol 24 (4), 334-8. PMID 24254265.
    Screening of celiac disease by anti-tissue transglutaminase antibody should be done as a routine investigation in children with iron-deficiency anemia. Biopsy should be r …
  • Iron Deficiency Anemia in Celiac Disease
    HJ Freeman. World J Gastroenterol 21 (31), 9233-8. PMID 26309349. - Review
    Iron is an important micronutrient that may be depleted in celiac disease. Iron deficiency and anemia may complicate well-established celiac disease, but may also be the …
  • Celiac Disease Prevalence in Patients With Iron Deficiency Anemia
    AH Çekın et al. Turk J Gastroenterol 23 (5), 490-5. PMID 23161292.
    Clinicians should consider celiac disease as a possible cause of anemia in all patients with iron deficiency anemia of obscure origin, even in menstruating women. Serolog …
  • Investigation of Iron Deficiency Anaemia
    S Bouri et al. Clin Med (Lond) 18 (3), 242-244. PMID 29858435. - Review
    Iron deficiency anaemia (IDA) is an important, common clinical condition and 8-15% of these patients will be diagnosed with a gastrointestinal cancer. IDA is defined as h …
See all similar articles

Cited by 7 PubMed Central articles

See all "Cited by" articles

Publication types