Role of the innate immune system in the development of chronic colitis

J Gastroenterol. 2002 Nov;37 Suppl 14:38-42. doi: 10.1007/BF03326411.


Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, Differentiation
  • Colitis / immunology
  • Colitis / physiopathology
  • Drosophila Proteins*
  • Humans
  • Immunity, Cellular / physiology*
  • Inflammatory Bowel Diseases / immunology*
  • Inflammatory Bowel Diseases / physiopathology*
  • Membrane Glycoproteins / analysis
  • Membrane Glycoproteins / immunology*
  • Prognosis
  • Receptors, Cell Surface / analysis
  • Receptors, Cell Surface / immunology*
  • Receptors, Immunologic / analysis
  • Risk Assessment
  • Sensitivity and Specificity
  • Toll-Like Receptors


  • Antigens, Differentiation
  • Drosophila Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Toll-Like Receptors