RUNX Transcription Factors as Key Targets of TGF-beta Superfamily Signaling

Curr Opin Genet Dev. 2003 Feb;13(1):43-7. doi: 10.1016/s0959-437x(03)00007-8.

Abstract

The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-beta and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-beta-induced tumor suppressor pathway. A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.

Publication types

  • Review

MeSH terms

  • Animals
  • Core Binding Factor Alpha 1 Subunit
  • Core Binding Factor Alpha 2 Subunit
  • Core Binding Factor Alpha 3 Subunit
  • Core Binding Factor alpha Subunits
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Mice
  • Mice, Knockout
  • Multigene Family / physiology
  • Neoplasm Proteins*
  • Proto-Oncogene Proteins*
  • Signal Transduction / physiology*
  • Smad Proteins
  • Smad1 Protein
  • Trans-Activators / physiology
  • Transcription Factor AP-2
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Transforming Growth Factor beta / physiology*

Substances

  • Core Binding Factor Alpha 1 Subunit
  • Core Binding Factor Alpha 2 Subunit
  • Core Binding Factor Alpha 3 Subunit
  • Core Binding Factor alpha Subunits
  • DNA-Binding Proteins
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • Runx1 protein, mouse
  • Runx2 protein, mouse
  • Runx3 protein, mouse
  • Smad Proteins
  • Smad1 Protein
  • Smad1 protein, mouse
  • Trans-Activators
  • Transcription Factor AP-2
  • Transcription Factors
  • Transforming Growth Factor beta