The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains

Trends Biochem Sci. 2003 Feb;28(2):69-74. doi: 10.1016/S0968-0004(03)00004-5.


We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Arabidopsis / genetics
  • Drosophila Proteins*
  • Evolution, Molecular
  • Humans
  • Insect Proteins / genetics*
  • Membrane Transport Proteins*
  • Minisatellite Repeats / genetics
  • Models, Molecular
  • Molecular Sequence Data
  • Plant Proteins / genetics*
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Sequence Homology, Amino Acid


  • Drosophila Proteins
  • Insect Proteins
  • Membrane Transport Proteins
  • Plant Proteins
  • tud protein, Drosophila