A high-protein diet enhances satiety without conditioned taste aversion in the rat

Physiol Behav. 2003 Feb;78(2):311-20. doi: 10.1016/s0031-9384(02)00977-0.


In order to determine the respective roles of conditioned food aversion, satiety and palatability, we studied behavioral responses to a 50% total milk protein diet, compared with those to a normal protein diet containing 14% total milk protein. Different paradigms were employed, including meal pattern analysis, two-choice testing, flavor testing, a behavioral satiety sequence (BSS) and taste reactivity. Our experiments showed that only behavioral and food intake parameters were disturbed during the first day when an animal ate the high-protein (P50) diet, and that most parameters returned to baseline values as soon as the second day of P50. Rats adapted to P50 did not acquire a conditioned taste aversion (CTA) but exhibited satiety, and a normal BSS. The initial reduction in high-protein diet intake appeared to result from the lower palatability of the food combined with the satiety effect of the high-protein diet and the delay required for metabolic adaptation to the higher protein level.

MeSH terms

  • Animals
  • Animals, Newborn / growth & development
  • Animals, Newborn / psychology
  • Avoidance Learning
  • Behavior, Animal / drug effects
  • Choice Behavior
  • Conditioning, Psychological
  • Dose-Response Relationship, Drug
  • Feeding Behavior / drug effects
  • Food Preferences
  • Grooming
  • Male
  • Milk Proteins / administration & dosage*
  • Motor Activity
  • Rats
  • Rats, Wistar
  • Rest
  • Satiety Response / drug effects*
  • Taste


  • Milk Proteins