A prospective randomized trial of the LoFric hydrophilic coated catheter versus conventional plastic catheter for clean intermittent catheterization

J Urol. 2003 Mar;169(3):994-8. doi: 10.1097/01.ju.0000051160.72187.e9.


Purpose: We compared the incidence of hematuria, pyuria and clinical urinary tract infection in patients who performed intermittent self-catheterization using a hydrophilic coated LoFric (Astra Tech AB, Mölndal, Sweden) or standard plastic catheter.

Materials and methods: A total of 62 male patients who performed intermittent self-catheterization to manage neurogenic bladder were randomized into 2 treatment groups at 3 American study sites. Outcome measures included urinary tract infection, microhematuria, pyuria and satisfaction rates.

Results: Of the 62 enrolled patients 49 completed the 12-month study. The withdrawal rate was not different in the 2 groups. At the end of the study there was statistically significantly less hematuria in the hydrophilic coated catheter group compared with controls. In addition, there was a significant decrease in the urinary tract infection rate from baseline in the hydrophilic coated catheter group but not in controls.

Conclusions: Use of the hydrophilic coated catheter by patients on intermittent self-catheterization is associated with less hematuria and a significant decrease in the incidence of urinary tract infections. Therefore, it may be preferable for some patients, especially those with a history of difficult catheterization, urethral trauma or a high rate of urinary tract infection.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bacteriuria / etiology
  • Catheterization* / adverse effects
  • Hematuria / etiology
  • Humans
  • Male
  • Patient Compliance
  • Polyvinyl Chloride
  • Prospective Studies
  • Surface Properties
  • Urinary Bladder, Neurogenic / therapy
  • Urinary Catheterization / adverse effects
  • Urinary Catheterization / instrumentation*
  • Urinary Tract Infections / etiology


  • Polyvinyl Chloride